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Rome and Florence in one week

Italy · Multi-city route · Updated July 2026

Rome and Florence is the perfect first multi-city trip: two unmissable cities, one 90-minute train, no flights inside the trip. With six nights, split them 4 in Rome, 2 in Florence — or 3+3 if Renaissance art is the reason you're going.

Why Rome gets the bigger share

Rome is simply bigger in every sense: three of the world's most time-hungry sights (Vatican Museums, Colosseum/Forum, and the historic centre itself), longer distances between them, and a pace that punishes cramming. Florence's centre, by contrast, is compact enough to cross on foot in twenty minutes — two full days covers the Uffizi, the Accademia, the Duomo climb and an evening in Oltrarno without rushing.

DayWhereWhat
1RomeArrive, centro storico wander: Pantheon, Piazza Navona, Trevi at night
2RomeColosseum + Forum + Palatine (one combined timed ticket)
3RomeVatican Museums early slot, St Peter's, Trastevere dinner
4RomeBorghese Gallery (timed, pre-book) or Testaccio food morning
5Train to Florence~90 min on the Frecciarossa; afternoon Duomo piazza, sunset at Piazzale Michelangelo
6FlorenceUffizi morning slot, Ponte Vecchio, Oltrarno artisans and dinner
7FlorenceAccademia (David) early, fly home from FLR or PSA — or train back to FCO

The train, solved

Rome Termini → Florence S.M.N. runs up to every 15–30 minutes on Trenitalia's Frecciarossa and Italo's high-speed sets. Book a week or two ahead for the cheap "Economy" fares; walk-up tickets on the day cost two to three times more. There's no security theatre — arrive 15 minutes early, validate nothing, sit down. This is why the day-trip crowd does it in reverse: Florence is an easy add to Rome, never the other way round.

What sells out (book these first)

Flying open-jaw saves a day

Fly into Rome and home from Florence (FLR) or Pisa (PSA, an hour from Florence) and you delete the backtracking leg entirely. If your dates force a Rome return, keep the last Florence morning light — the train plus FCO's queues need more buffer than people give them.

Planning this trip? Add Rome and Florence as stops in ConMigo and it slices your nights, marks the train day, and builds the day-by-day plan — including flagging the timed-entry sights above so you book them before they're gone.